1H-Imidazole-1-ethanol, 2-methyl-5-nitro-
Synonyms
Metronidazole;
Imidazole-1-ethanol, 2-methyl-5-nitro-;
Category
Non-ionic surfactant
> Amine
>> Heteroaromatic Amine
>>> Imidazole and its Derivatives
Chemical Numbering System
CASRN: 443-48-1
EINECS: 207-136-1
Molecular Formula & Molecular Weight
Molecular Formula: C6H9N3O3
Molecular Weight: 171.15
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Physical - chemical properties
|
Water solubility, g/L |
11 (25 °C)[1] |
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS (Rev.10) label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
870mg/kg[2] |
|
mouse oral LD50 |
3800mg/kg[2] |
|
mouse subcutaneous LD50 |
3640mg/kg[2] |
|
rat oral LD50 |
3000mg/kg[2] |
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
39600mg/kg/4W[2] |
|
man oral TDLo |
3.57mg/kg/D[2] |
|
man oral TDLo |
1030mg/kg/8W[2] |
|
women intravenous TDLo |
100mg/kg/5D-I[2] |
|
women oral TDLo |
12mg/kg[2] |
|
women oral TDLo |
40mg/kg[2] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, anti-infective, antiprotozoal abilities. Not to be used in personal care products.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Metronidazole
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antibacterial agent, antiprotozoal agent.
2, Medicine
Use as pharmaceutical ingredient (antianaerobic-microbacterial drug, antitrichomonal agent). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: HSDB. 443-48-1, Metronidazole
[2]: ChemIDplus. 443-48-1, Metronidazole