Artemisinin
Synonyms
(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one;
Category
Non-ionic surfactant
> Peroxide
Chemical Numbering System
CASRN: 63968-64-9
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: C15H22O5
Molecular Weight: 282.33
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable. Unstable to heat.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong reductants, can cause to burn.
GHS (Rev.10) label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intramuscular LD |
> 800mg/kg[1] |
|
mouse intramuscular LD50 |
2800mg/kg[1] |
|
mouse intraperitoneal LD50 |
1558mg/kg[1] |
|
mouse oral LD50 |
4228mg/kg[1] |
|
rat intramuscular LD50 |
2571mg/kg[1] |
|
rat oral LD50 |
5576mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-malarial, bacteriostatic abilities. The peroxy bridge is an active structure.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Artemisinin
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimalarial component.
2, Personal care products
Antimicrobial agent, conditioning agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (antimalarial drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 63968-64-9, Artemisinin