Chlorpheniramine maleate
Synonyms
2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);
Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1);
DL-Chlorpheniramine maleate;
Category
Non-ionic surfactant
> Amine
>> Heteroaromatic Amine
>>> Pyridine and its Derivatives
Chemical Numbering System
CASRN: 113-92-8
EINECS: 204-037-5
Molecular Formula & Molecular Weight
Molecular Formula: C20H23ClN2O4; C16H19Cl1N2.C4H4O4
Molecular Weight: 390.86
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS (Rev.10) label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LD50 |
97.6mg/kg[1] |
|
guinea pig intravenous LD50 |
68mg/kg[1] |
|
guinea pig oral LD50 |
198mg/kg[1] |
|
guinea pig subcutaneous LD50 |
101mg/kg[1] |
|
mouse intraperitoneal LD50 |
76.7mg/kg[1] |
|
mouse intravenous LD50 |
26.1mg/kg[1] |
|
mouse oral LD50 |
130mg/kg[1] |
|
mouse subcutaneous LD50 |
104mg/kg[1] |
|
rat oral LD50 |
306mg/kg[1] |
|
rat subcutaneous LD50 |
365mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/Kg, ≤ |
20 |
|
As, mg/Kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Chlorpheniramine maleate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (antihistamine). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 113-92-8, Chlorpheniramine maleate