Metolazone
Synonyms
6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-;
Category
Non-ionic surfactant
> Amine
>> Amido-group Amine
>>> Lactam-group Amine
Chemical Numbering System
CAS: 17560-51-9
EINECS: 241-539-3
Molecular Formula & Molecular Weight
Molecular Formula: C16H16ClN3O3S; C16H16Cl1N3O3S
Molecular Weight: 365.83
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
> 1500mg/kg[1] |
|
mouse oral LD50 |
> 5000mg/kg[1] |
|
mouse subcutaneous LD50 |
> 5000mg/kg[1] |
|
rat intraperitoneal LD50 |
> 5000mg/kg[1] |
|
rat oral LD50 |
> 5000mg/kg[1] |
|
rat subcutaneous LD50 |
> 5000mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
2mg/kg/2W-I[1] |
|
women oral TDLo |
0.15mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent diuretic, antihypertensive, dispersing, emulsifying, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (diuretic, antihypertensive drug). (For reference only.)
Manufacturers
References
[1]: ChemIDplus. 17560-51-9, Metolazone
Update: 20200822(1);