Bupivacaine hydrochloride
Synonyms
2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride;
Bupivacaine HCl;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 18010-40-7
EINECS: 241-917-8
Molecular Formula & Molecular Weight
Molecular Formula: C18H29ClN2O; C18H28N2O.HCl
Molecular Weight: 324.89
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
guinea pig intraperitoneal LD50 |
50mg/kg[1] |
|
mouse intramuscular LD50 |
22.753mg/kg[1] |
|
mouse intraperitoneal LD50 |
58.7mg/kg[1] |
|
mouse intravenous LD50 |
6.1mg/kg[1] |
|
mouse subcutaneous LD50 |
59mg/kg[1] |
|
rabbit intratracheal LD50 |
11mg/kg[1] |
|
rabbit intravenous LD50 |
3.4mg/kg[1] |
|
rabbit oral LD50 |
18mg/kg[1] |
|
rabbit parenteral LD50 |
48mg/kg[1] |
|
rat intravenous LD50 |
6mg/kg[1] |
|
rat parenteral LD50 |
30mg/kg[1] |
|
rat subcutaneous LD50 |
43mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent local anesthetic, antistatic, emulsifying, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Bupivacaine Hydrochloride
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (local anesthetic agent). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 18010-40-7, Bupivacaine hydrochloride
Update: 20200808(1);