Danazol
Synonyms
Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, (17alpha)-;
Category
Non-ionic surfactant
> Amine
>> Heteroaromatic Amine
>>> Azafuran and its Derivatives
Chemical Numbering System
CAS: 17230-88-5
EINECS: 241-270-1
Molecular Formula & Molecular Weight
Molecular Formula: C22H27NO2; C22H27N1O2
Molecular Weight: 337.46
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog oral LD50 |
> 5000mg/kg[1] |
|
mouse intraperitoneal LD50 |
6770mg/kg[1] |
|
mouse oral LD50 |
4830mg/kg[1] |
|
mouse subcutaneous LD50 |
> 10000mg/kg[1] |
|
rabbit oral LD50 |
> 5000mg/kg[1] |
|
rat intraperitoneal LD50 |
> 10000mg/kg[1] |
|
rat oral LD50 |
> 17000mg/kg[1] |
|
rat subcutaneous LD50 |
> 10000mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
274mg/kg/32D-[1] |
|
man oral TDLo |
1029mg/kg/17W[1] |
|
women oral TDLo |
120mg/kg/10D-[1] |
|
women oral TDLo |
974mg/kg/23W-[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, emulsifying, dispersing abilities. Hormones. Anti-estrogenic.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Danazol
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (gonadotropin inhibitor). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 17230-88-5, Danazol
Update: 20200905(1);