Dextropropoxyphene hydrochloride
Synonyms
Benzeneethanol, alpha-((1R)-2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, 1-propanoate, hydrochloride (1:1), (alphaS)-;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 1639-60-7
EINECS: 216-683-5
Molecular Formula & Molecular Weight
Molecular Formula: C22H30ClNO2; C22H29N1O2.HCl
Molecular Weight: 375.93
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intramuscular LD50 |
65mg/kg[1] |
|
dog intraperitoneal LD50 |
> 38mg/kg[1] |
|
dog intravenous LD50 |
29mg/kg[1] |
|
dog oral LD50 |
100mg/kg[1] |
|
mouse intraperitoneal LD50 |
111mg/kg[1] |
|
mouse intravenous LD50 |
25mg/kg[1] |
|
mouse oral LD50 |
225mg/kg[1] |
|
mouse subcutaneous LD50 |
170mg/kg[1] |
|
rabbit oral LD50 |
82mg/kg[1] |
|
rat intramuscular LD50 |
157mg/kg[1] |
|
rat intraperitoneal LD50 |
58mg/kg[1] |
|
rat intravenous LD50 |
15mg/kg[1] |
|
rat oral LD50 |
84mg/kg[1] |
|
rat subcutaneous LD50 |
134mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
child oral LDLo |
70mg/kg[1] |
|
child oral TDLo |
27mg/kg[1] |
|
man oral TDLo |
11mg/kg[1] |
|
man oral TDLo |
37mg/kg[1] |
|
women oral LDLo |
15mg/kg[1] |
|
women oral TDLo |
0.0013mg/kg[1] |
|
women oral TDLo |
0.65mg/kg[1] |
|
women oral TDLo |
90mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent analgesic, antistatic, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (analgesic). (For reference only.)
Manufacturers
References
[1]: ChemIDplus. 1639-60-7, Propoxyphene hydrochloride
Update: 20200815(1);