Dextropropoxyphene Napsylate
Synonyms
Naphthalene-2-sulphonic acid, compound with (S-(R*,S*))-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate (1:1);
2-Naphthalenesulfonic acid, compd. with (1S,2R)-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)propyl propanoate (1:1);
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 17140-78-2
EINECS: 241-205-7
Molecular Formula & Molecular Weight
Molecular Formula: C32H37NO5S; C22H29N1O2.C10H8O3S
Molecular Weight: 547.70
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse oral LD50 |
915mg/kg[1] |
|
rabbit oral LDLo |
183mg/kg[1] |
|
rat oral LD50 |
647mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
129mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent analgesic, antistatic, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Dextropropoxyphene Napsylate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (analgesic). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 17140-78-2, Propoxyphene napsylate
Update: 20200815(1);