Tobramycin sulfate
Synonyms
D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-, sulfate (2:5)(salt);
Category
Non-ionic surfactant
> Sugar-type
>> Aminosaccharide and its Derivatives
Chemical Numbering System
CAS: 49842-07-1
EINECS: 256-499-2
Molecular Formula & Molecular Weight
Molecular Formula: C36H84N10O38S5; C18H37N5O9.5/2H2SO4
Molecular Weight: 1425.42
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxide and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
262mg/kg[1] |
|
mouse intravenous LD50 |
77mg/kg[1] |
|
mouse oral LD50 |
> 10500mg/kg[1] |
|
mouse subcutaneous LD50 |
560mg/kg[1] |
|
rat intravenous LD50 |
126mg/kg[1] |
|
rat subcutaneous LD50 |
1680mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
women intravenous LDLo |
15mg/kg/5D-I[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antimicrobial agent, antibacterial agent.
Manufacturers
References
[1]: ChemIDplus. 49842-07-1, Tobramycin sulfate
Update: 20190929(1)