Digoxin
Synonyms
Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-;
Category
Non-ionic surfactant
> Sugar-type
>> Glycoside
Chemical Numbering System
CAS: 20830-75-5
EINECS: 244-068-1
Molecular Formula & Molecular Weight
Molecular Formula: C41H64O14
Molecular Weight: 780.94
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
cat oral LD50 |
0.2mg/kg[1] |
|
cat intraduodenal LDLo |
0.441mg/kg[1] |
|
cat intravenous LDLo |
0.159mg/kg[1] |
|
cat parenteral LDLo |
1.47mg/kg[1] |
|
dog intravenous LDLo |
0.2mg/kg[1] |
|
dog oral LDLo |
0.3mg/kg[1] |
|
frog subcutaneous LD50 |
0.00224mg/kg[1] |
|
frog parenteral LDLo |
1mg/kg[1] |
|
guinea pig intraduodenal LD50 |
3.2mg/kg[1] |
|
guinea pig intramuscular LD50 |
0.63mg/kg[1] |
|
guinea pig intraperitoneal LD50 |
0.8mg/kg[1] |
|
guinea pig oral LD50 |
3.5mg/kg[1] |
|
guinea pig subcutaneous LD50 |
0.6mg/kg[1] |
|
guinea pig intravenous LDLo |
0.468mg/kg[1] |
|
mouse intracerebral LD50 |
0.124mg/kg[1] |
|
mouse intraperitoneal LD50 |
3.964mg/kg[1] |
|
mouse intravenous LD50 |
7.67mg/kg[1] |
|
mouse oral LD50 |
17.78mg/kg[1] |
|
mouse subcutaneous LD50 |
0.00815mg/kg[1] |
|
mouse parenteral LDLo |
2.947mg/kg[1] |
|
pig intraduodenal LDLo |
1.58mg/kg[1] |
|
pig intravenous LDLo |
0.23mg/kg[1] |
|
pigeon intravenous LDLo |
0.337mg/kg[1] |
|
pigeon parenteral LDLo |
0.45mg/kg[1] |
|
rabbit intravenous LD50 |
3.56mg/kg[1] |
|
rat intraperitoneal LD50 |
4mg/kg[1] |
|
rat intravenous LD50 |
25mg/kg[1] |
|
rat oral LD50 |
28.27mg/kg[1] |
|
rat subcutaneous LD50 |
0.0089mg/kg[1] |
|
rat rectal LDLo |
5mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
child oral TDLo |
0.054mg/kg[1] |
|
child oral TDLo |
0.127mg/kg[1] |
|
infant intravenous LDLo |
0.2mg/kg[1] |
|
infant intravenous TDLo |
0.05mg/kg[1] |
|
man oral TDLo |
0.075mg/kg[1] |
|
man oral TDLo |
0.333mg/kg[1] |
|
women oral TDLo |
0.1mg/kg[1] |
|
women oral TDLo |
0.165mg/kg/33D-[1] |
|
women oral TDLo |
0.5mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent emulsifying, dispersing, solubilizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Digoxin
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (cardiotonic drug). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 20830-75-5, Digoxin
Update: 20191014(1)