Ibuprofen
Synonyms
Hydratropic acid, p-isobutyl-;
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-;
Category
Anionic Surfactant
> Carboxylate
>> Chain Carboxylate
>>> Phenyl Alkyl Carboxylate
>>>> Branched Alkylphenyl Linear Alkylcarboxylate
Chemical Numbering System
CAS: 15687-27-1
EINECS: 239-784-6
Molecular Formula & Molecular Weight
Molecular Formula: C13H18O2
Molecular Weight: 206.28
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
guinea pig oral LD50 |
495mg/kg[1] |
|
hamster oral LD50 |
1690mg/kg[1] |
|
mouse intraperitoneal LD50 |
320mg/kg[1] |
|
mouse oral LD50 |
740mg/kg[1] |
|
mouse rectal LD50 |
620mg/kg[1] |
|
mouse subcutaneous LD50 |
395mg/kg[1] |
|
rabbit oral LD50 |
1400mg/kg[1] |
|
rabbit rectal LD50 |
830mg/kg[1] |
|
rat intraperitoneal LD50 |
626mg/kg[1] |
|
rat oral LD50 |
636mg/kg[1] |
|
rat rectal LD50 |
530mg/kg[1] |
|
rat subcutaneous LD50 |
740mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
child oral LDLo |
469mg/kg[1] |
|
child oral TDLo |
480mg/kg/17D-[1] |
|
child oral TDLo |
500mg/kg[1] |
|
man oral LDLo |
171mg/kg[1] |
|
man oral TDLo |
120mg/kg/W-I[1] |
|
man oral TDLo |
180mg/kg/3W-I[1] |
|
man oral TDLo |
429mg/kg[1] |
|
man oral TDLo |
800mg/kg[1] |
|
man oral TDLo |
1028mg/kg[1] |
|
women oral TDLo |
8mg/kg[1] |
|
women oral TDLo |
132mg/kg/6D-I[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, analgesic, emulsifying, dispersing, solubilizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
GB/T 5173 Surface active agents and detergents -- Determination of anionic-active matter by direct two-phase titration procedure
ISO 2271 Surface active agents -- Detergents -- Determination of anionic-active matter by manual or mechanical direct two-phase titration procedure
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Ibuprofen
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as emulsifying agent, dispersing agent.
2, Personal care products
Conditioning agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (nonsteroidal anti-inflammatory agent). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 15687-27-1, Ibuprofen
Update: 20140309(1); 20181008(2);