Bleomycin A5 hydrochloride
Synonyms
Bleomycin A5 HCl;
Bleomycinamide, N1-(3-((4-aminobutyl)amino)propyl)-, hydrochloride;
Category
Non-ionic surfactant
> Amine
>> Peptide and its Derivatives
Chemical Numbering System
CAS: 55658-47-4
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: C57H89N19O21S2.x-HCl
Molecular Weight: N/A
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
66mg/kg[1] |
|
mouse intravenous LD50 |
50mg/kg[1] |
|
mouse oral LD50 |
800mg/kg[1] |
|
mouse subcutaneous LD50 |
67mg/kg[1] |
|
rat intramuscular LD50 |
102mg/kg[1] |
|
rat intraperitoneal LD50 |
117mg/kg[1] |
|
rat intravenous LD50 |
75mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antineoplastic, antistatic abilities. Glycopeptide.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Bleomycin A5 Hydrochloride
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (antineoplastic antibiotics).
Manufacturers
References
[1]: ChemIDplus. 55658-47-4, Bleomycin A5 hydrochloride
Update: 20200718(1);