Bleomycin
Synonyms
Bleomycine;
Category
Cationic surfactant
> Sulfonium Salt
Chemical Numbering System
CAS: 11056-06-7
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Bleomycin A2:
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog oral LD |
> 100mg/kg[1] |
|
mouse intramuscular LD50 |
270mg/kg[1] |
|
mouse intraperitoneal LD50 |
35mg/kg[1] |
|
mouse intravenous LD50 |
53mg/kg[1] |
|
mouse oral LD50 |
> 2000mg/kg[1] |
|
mouse subcutaneous LD50 |
188mg/kg[1] |
|
mouse intratracheal LDLo |
14mg/kg[1] |
|
rat oral LD |
> 200mg/kg[1] |
|
rat intraperitoneal LD50 |
168mg/kg[1] |
|
rat subcutaneous LD50 |
168mg/kg[1] |
|
rat intratracheal LDLo |
4units/kg[1] |
Reproductive effect[1]. Overall carcinogenic evaluation: Group 2B[1].
Human Toxicity
Table 2 Human toxicity values
|
human intramuscular LDLo |
418mg/kg[1] |
|
human intravenous LDLo |
351mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antineoplastic, antibacterial, antistatic abilities.
Note (1). Main ingredients: bleomycin A2 and bleomycin B2.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient.
Manufacturers
References
[1]: ChemIDplus. 11056-06-7, Bleomycin
Update: 20190401(1);