Podophyllin
Synonyms
Podophyllum (resin);
Category
Natural Surfactant
> Plant Extract
>> Multicomponent Extract
Chemical Numbering System
CAS: 9000-55-9
EINECS: 232-546-2
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Properties
Appearance (1), solid.
Solubility soluble in boiling water.
Stability stable.
Risk Solid form: flammable material; irritation, strong irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse oral LD50 |
68mg/kg[1] |
|
mouse subcutaneous LD50 |
58mg/kg[1] |
|
rat intraperitoneal LD50 |
15mg/kg[1] |
|
rat parenteral LD50 |
25mg/kg[1] |
|
rat subcutaneous LD50 |
18mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
man oral LDLo |
157mg/kg[1] |
|
man oral TDLo |
1333mg/kg[1] |
|
women oral LDLo |
6mg/kg[1] |
|
women oral TDLo |
80mg/kg[1] |
Reproductive effect[1].
Teratogenesis[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antineoplastic, antibacterial abilities. Contain podophyllotoxin.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (For reference only.).
Manufacturers
References
[1]: ChemIDplus. 9000-55-9, Podophyllum resin
Update: 20201205(1);