Quinidine sulfate
Synonyms
Quinidine sulfate, (2:1) (salt);
Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate (2:1);
Category
Non-ionic surfactant
> Amine
>> Heteroaromatic Amine
>>> Quinoline and its Derivatives
Chemical Numbering System
CAS: 50-54-4
EINECS: 200-046-3
Molecular Formula & Molecular Weight
Molecular Formula: C40H50N4O8S; C20H24N2O2.1/2H2SO4
Molecular Weight: 746.91
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
cat intravenous LD50 |
16mg/kg[1] |
|
dog intravenous LDLo |
19mg/kg[1] |
|
guinea pig oral LD50 |
362mg/kg[1] |
|
guinea pig intravenous LDLo |
117mg/kg[1] |
|
mouse intraperitoneal LD50 |
135mg/kg[1] |
|
mouse intravenous LD50 |
54mg/kg[1] |
|
mouse oral LD50 |
505mg/kg[1] |
|
rabbit intravenous LD50 |
30mg/kg[1] |
|
rat intravenous LD50 |
55mg/kg[1] |
|
rat oral LD50 |
456mg/kg[1] |
|
rat subcutaneous LD50 |
610mg/kg[1] |
|
rat intraperitoneal LDLo |
140mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
9600mg/kg/8W[1] |
|
man oral TDLo |
88mg/kg/10D-I[1] |
|
man oral TDLo |
240mg/kg/2W-I[1] |
|
man oral TDLo |
386mg/kg/30D-[1] |
|
women oral TDLo |
32mg/kg/2D[1] |
|
women oral TDLo |
272mg/kg/17D-[1] |
|
women oral TDLo |
409000mg/kg/14Y[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent dispersing, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Quinidine Sulfate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (antiarrhythmic drug) (For reference only, should be implemented according to local Pharmacopoeia.).
Manufacturers
References
[1]: ChemIDplus. 50-54-4, Quinidine sulfate anhydrous
Update: 20200830(1);