Streptozocin
Synonyms
Streptozotocin;
D-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-;
D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-;
Category
Non-ionic surfactant
> Sugar-type
>> Aminosaccharide and its Derivatives
Chemical Numbering System
CAS: 18883-66-4
EINECS: 242-646-8
Molecular Formula & Molecular Weight
Molecular Formula: C8H15N3O7
Molecular Weight: 265.22
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxide and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LD50 |
50mg/kg[1] |
|
monkey intravenous LDLo |
80mg/kg[1] |
|
mouse intraperitoneal LD50 |
360mg/kg[1] |
|
mouse intravenous LD50 |
275mg/kg[1] |
|
mouse parenteral LD50 |
264mg/kg[1] |
|
mouse subcutaneous LD50 |
335mg/kg[1] |
|
rat intravenous LD50 |
138mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
human intravenous TDLo |
1044mg/kg/5D[1] |
|
women intravenous LDLo |
440mg/kg/65W-[1] |
|
women intravenous TDLo |
13.513mg/kg[1] |
Overall carcinogenic evaluation: Group 2B[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antineoplastic, antibacterial, dispersing abilities. Lead to diabetes.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antibacterial agent.
Manufacturers
References
[1]: ChemIDplus. 18883-66-4, Streptozocin
Update: 20190929(1)