Ipratropium bromide
Synonyms
8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy) -8-methyl-8-(1-methylethyl)-, bromide, (3-endo,8-syn)-;
Category
Cationic surfactant
> Quaternary Ammonium Salt
>> Aliphatic Heterocyclic Quaternary Ammonium Salt
Chemical Numbering System
CAS: 22254-24-6
EINECS: 244-873-8
Molecular Formula & Molecular Weight
Molecular Formula: C20H30BrNO3; C20H30N1O3.Br
Molecular Weight: 412.36
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, strong irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog oral LD50 |
1300mg/kg[1] |
|
dog intravenous LDLo |
20mg/kg[1] |
|
mouse intraperitoneal LD50 |
72mg/kg[1] |
|
mouse intravenous LD50 |
12.29mg/kg[1] |
|
mouse oral LD50 |
1001mg/kg[1] |
|
mouse subcutaneous LD50 |
300mg/kg[1] |
|
rabbit oral LD50 |
1557mg/kg[1] |
|
rat intraperitoneal LD50 |
113mg/kg[1] |
|
rat intravenous LD50 |
15.7mg/kg[1] |
|
rat oral LD50 |
1663mg/kg[1] |
|
rat subcutaneous LD50 |
635mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
man inhalation TCLo |
0.001mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, antibacterial, antimicrobial, preservative, solubilizing, emulsifying, dispersing, anticorrosive abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
GB/T 5174 Surface active agents -- Detergents -- Determination of cationic-active matter content
ISO 2871-1 Surface active agents -- Detergents -- Determination of cationic-active matter content -- Part 1: High-molecular-mass cationic-active matter
ISO 2871-2 Surface active agents -- Detergents -- Determination of cationic-active matter content -- Part 2: Cationic-active matter of low molecular mass (between 200 and 500)
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antimicrobial agent, preservative.
Use as antistatic agent.
Use as emulsifying agent, dispersing agent.
Use as flocculant.
Use as pharmaceutical ingredient (For reference only.).
Manufacturers
References
[1]: ChemIDplus. 22254-24-6, Ipratropium bromide
Update: 20190609(1);