Diflunisal
Synonyms
(1,1'-Biphenyl)-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-;
3-Biphenylcarboxylic acid, 2',4'-difluoro-4-hydroxy-;
Category
Anionic Surfactant
> Carboxylate
>> Cyclic Carboxylate
>>> Aryl Carboxylate
>>>> Halophenyl Hydroxybenzoate
Chemical Numbering System
CAS: 22494-42-4
EINECS: 245-034-9
Molecular Formula & Molecular Weight
Molecular Formula: C13H8F2O3
Molecular Weight: 250.20
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
124mg/kg[1] |
|
mouse oral LD50 |
439mg/kg[1] |
|
mouse subcutaneous LD50 |
212mg/kg[1] |
|
rabbit oral LD50 |
603mg/kg[1] |
|
rat intraperitoneal LD50 |
159mg/kg[1] |
|
rat oral LD50 |
392mg/kg[1] |
|
rat subcutaneous LD50 |
185mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
71mg/kg/5D-I[1] |
|
man oral TDLo |
429mg/kg/17W-[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Diflunisal
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
2, Medicine
Use as pharmaceutical ingredient (antipyretic, analgesic, non-steroidal anti-inflammatory drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 22494-42-4, Diflunisal
Update: 20181112(1);