Prazosin
Synonyms
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-;
Category
Non-ionic surfactant
> Amine
>> Heteroaromatic Amine
>>> Pyrimidine and its Derivatives
Chemical Numbering System
CAS: 19216-56-9
EINECS: 242-885-8
Molecular Formula & Molecular Weight
Molecular Formula: C19H21N5O4
Molecular Weight: 383.40
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intravenous LD50 |
> 400mg/kg[1] |
|
mouse oral LD50 |
> 4000mg/kg[1] |
|
rat oral LD |
> 3000mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
0.28mg/kg[1] |
|
human oral TDLo |
1.26mg/kg[1] |
|
man oral TDLo |
1.143mg/kg[1] |
|
women oral TDLo |
0.02mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (antihypertensive drugs) (For reference only.).
Manufacturers
References
[1]: ChemIDplus. 19216-56-9, Prazosin
Update: 20200905(1);