Trazodone hydrochloride
Synonyms
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, monohydrochloride;
Category
Non-ionic surfactant
> Amine
>> Heteroaromatic Amine
>>> Triazole and its Derivatives
Chemical Numbering System
CAS: 25332-39-2
EINECS: 246-855-5
Molecular Formula & Molecular Weight
Molecular Formula: C19H23Cl2N5O; C19H22Cl1N5O.HCl
Molecular Weight: 408.32
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LD50 |
> 40mg/kg[1] |
|
dog oral LD50 |
500mg/kg[1] |
|
monkey intravenous LD50 |
25mg/kg[1] |
|
mouse intraperitoneal LD50 |
255mg/kg[1] |
|
mouse intravenous LD50 |
91mg/kg[1] |
|
mouse oral LD50 |
584mg/kg[1] |
|
mouse subcutaneous LD50 |
> 1500mg/kg[1] |
|
rabbit intravenous LD50 |
52mg/kg[1] |
|
rabbit oral LD50 |
560mg/kg[1] |
|
rat intraperitoneal LD50 |
178mg/kg[1] |
|
rat intravenous LD50 |
91mg/kg[1] |
|
rat oral LD50 |
690mg/kg[1] |
|
rat subcutaneous LD50 |
2729mg/kg[1] |
Reproductive effect.
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
0.667mg/kg[1] |
|
man oral TDLo |
5.714mg/kg/4D-[1] |
|
man oral TDLo |
43mg/kg/30D-I[1] |
|
man oral TDLo |
46mg/kg/8D-I[1] |
|
women oral TDLo |
0.75mg/kg[1] |
|
women oral TDLo |
80mg/kg[1] |
|
women oral TDLo |
100mg/kg[1] |
|
women oral TDLo |
720mg/kg/34W-[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anticorrosive, emulsifying, antistatic, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (antidepressant) (For reference only.).
Use as emulsifying agent, dispersing agent.
Use as antistatic agent.
Manufacturers
References
[1]: ChemIDplus. 25332-39-2, Trazodone hydrochloride
Update: 20200830(1);