Dinoprostone
Synonyms
Prosta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo-;
Category
Anionic Surfactant
> Carboxylate
>> Chain Carboxylate
>>> Prostaglandin and Its Derivatives
Chemical Numbering System
CAS: 363-24-6
EINECS: 206-656-6
Molecular Formula & Molecular Weight
Molecular Formula: C20H32O5
Molecular Weight: 352.47
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
hamster intraperitoneal LD50 |
1mg/kg[1] |
|
mouse intravenous LD50 |
23.2mg/kg[1] |
|
mouse oral LD50 |
750mg/kg[1] |
|
mouse subcutaneous LD50 |
19.7mg/kg[1] |
|
rat intravenous LD50 |
59.5mg/kg[1] |
|
rat oral LD50 |
500mg/kg[1] |
|
rat subcutaneous LD50 |
31.6mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent emulsifying, dispersing, solubilizing abilities. Hormone.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
GB/T 5173 Surface active agents and detergents -- Determination of anionic-active matter by direct two-phase titration procedure
ISO 2271 Surface active agents -- Detergents -- Determination of anionic-active matter by manual or mechanical direct two-phase titration procedure
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient. (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 363-24-6, Dinoprostone
Update: 20181008(1);