Clobetasone butyrate
Synonyms
Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16beta)-;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 25122-57-0
EINECS: 246-635-9
Molecular Formula & Molecular Weight
Molecular Formula: C26H32ClFO5; C26H32Cl1F1O5
Molecular Weight: 478.98
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
500mg/kg[1] |
|
mouse oral LD50 |
> 6000mg/kg[1] |
|
mouse subcutaneous LD50 |
> 3600mg/kg[1] |
|
rat intraperitoneal LD50 |
1510mg/kg[1] |
|
rat oral LD50 |
> 6000mg/kg[1] |
|
rat subcutaneous LD50 |
> 2600mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent lubricating, dispersing, emulsifying, solubilizing, anti-inflammatory abilities. Hormone.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as lubricant.
Use as dispersing agent, emulsion stabilizer.
Use as anti-inflammatory agent.
Manufacturers
References
[1]: ChemIDplus. 25122-57-0, Clobetasone butyrate
Update: 20200718(1);