Lidocaine hydrochloride monohydrate
Synonyms
Lidocaine HCl;
Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride, monohydrate;
Category
Non-ionic surfactant
> Amine
>> Amine-group Carboxylic Acid Amide
>>> Fatty Amine-group Carboxylic Acid Acyl Arylamine
>>>> Tertiary Amine-group Carboxylic Acid Acyl Arylamine
Chemical Numbering System
CAS: 6108-05-0
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: C14H25ClN2O2; C14H22N2O.HCl.H2O
Molecular Weight: 288.81
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse oral LD50 |
292mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Lidocaine Hydrochloride
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antistatic agent.
Use as emulsifying agent, dispersing agent.
2, Medicine
Use as pharmaceutical ingredient (local anesthetic, antiarrhythmic drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 6108-05-0, Lidocaine hydrochloride monohydrate
Update: 20200718(1);