Lidocaine

Lidocaine

Synonyms

Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-;

2',6'-Acetoxylidide, 2-(diethylamino)-;

Category

Non-ionic surfactant

> Amine

>> Amine-group Carboxylic Acid Amide

>>> Fatty Amine-group Carboxylic Acid Acyl Arylamine

>>>> Tertiary Amine-group Carboxylic Acid Acyl Arylamine

Chemical Numbering System

CAS: 137-58-6

EINECS: 205-302-8

Molecular Formula & Molecular Weight

Molecular Formula: C14H22N2O

Molecular Weight: 234.34

Structure

Properties

Appearance    (1), solid.

Solubility    slightly soluble in water.

Stability    stable.

Risk    Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.

GHS label:  

Animal Toxicity

Table 1 Animal toxicity values

guinea pig subcutaneous LD50	120mg/kg[1]
guinea pig intravenous LDLo	65mg/kg[1]
mouse intraperitoneal LD50	102mg/kg[1]
mouse intravenous LD50	20mg/kg[1]
mouse oral LD50	220mg/kg[1]
mouse subcutaneous LD50	238mg/kg[1]
rabbit intravenous LDLo	41mg/kg[1]
rat intraperitoneal LD50	133mg/kg[1]
rat intravenous LD50	18mg/kg[1]
rat oral LD50	317mg/kg[1]
rat subcutaneous LD50	335mg/kg[1]

Human Toxicity

Table 2 Human toxicity values

child oral TDLo	21mg/kg[1]
child oral TDLo	300mg/kg/5D-I[1]
human intravenous TDLo	23mg/kg[1]
man intravenous TDLo	1.7mg/kg/2M-[1]
man intravenous TDLo	8.643mg/kg/4H-[1]
women intraspinal TDLo	1mL/kg[1]
women intravenous TDLo	16mg/kg[1]
women oral TDLo	39mg/kg[1]

Ecology    may be hazardous to environment. Water body should be given special attention.

Biodegradability    biodegradable.

Characteristics    excellent antistatic, dispersing, emulsifying abilities.

Synthesis

 

Quality Standards & Test Methods

1, Physical and chemical indexes

Item	Physical and chemical indexes
	Solid
Actives, %, ≥	95.0

Test Methods

(1), Actives

GB/T 13173 Surface active agents -- Detergents -- Testing methods

2, Hazardous substances indexes

Item	Hazardous substances indexes
	Solid
Heavy metals (as Pb), mg/kg, ≤	20
As, mg/kg, ≤	3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents -- Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents -- Determination of total arsenic

3, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

Major Uses

1, Typical applications

Use as pharmaceutical ingredient.

Use as antistatic agent.

Use as emulsifying agent, dispersing agent.

Manufacturers

 

References

[1]: ChemIDplus. 137-58-6, Lidocaine

Update: 20200718(1);