Tazarotene
Synonyms
3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester;
Category
Non-ionic surfactant
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>> Ester-group Amine
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Chemical Numbering System
CAS: 118292-40-3
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: C21H21NO2S; C21H21N1O2S
Molecular Weight: 351.46
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat oral LD |
> 2000mg/kg[1] |
Teratogenic effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, antibacterial, dispersing, emulsifying, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Tazarotene
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
Use as antistatic agent.
2, Personal care products
Conditioning agent, exfoliating agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (anti-keratinization drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 118292-40-3, Tazarotene
Update: 20200815(1);