Methenamine
Synonyms
1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane;
Hexamethylenetetramine;
Category
Non-ionic surfactant
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>>> Hexamethylenetetramine and its Derivatives
Chemical Numbering System
CAS: 100-97-0
EINECS: 202-905-8
Molecular Formula & Molecular Weight
Molecular Formula: C6H12N4
Molecular Weight: 140.19
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
cat parenteral LDLo |
200mg/kg[1] |
|
cat subcutaneous LDLo |
200mg/kg[1] |
|
guinea pig subcutaneous LDLo |
300mg/kg[1] |
|
mouse intravenous LD50 |
17.7mL/kg[1] |
|
mouse oral LD50 |
569mg/kg[1] |
|
mouse subcutaneous LD50 |
215mg/kg[1] |
|
mouse parenteral LDLo |
450mg/kg[1] |
|
rat intravenous LD50 |
9200mg/kg[1] |
|
rat parenteral LDLo |
200mg/kg[1] |
|
rat subcutaneous LDLo |
200mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative, emulsifying, dispersing, lubricating, anticorrosive, antistatic abilities. Under acidic condition: formaldehyde donor.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Methenamine
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimicrobial agent, preservative.
Use as emulsifying agent, dispersing agent.
Use as lubricant, corrosion inhibitor.
Use as antistatic agent.
Use as intermediate in organic synthesis.
2, Personal care products
Preservative, antimicrobial agent in personal care products.
Further information:
(1), In accordance with EU regulations (EC) No 1223/2009, directive 2007/17/EC, be included in Annex V/30.
Maximum concentration is 0.15%.
3, Machinery
Corrosion inhibitor in industrial cleaning, metal working fluids.
4, Medicine
Use as pharmaceutical ingredient (disinfectant and antiseptic). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 519-02-8, Matrine
Update: 20200808(1);