Triclosan
Synonyms
Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-;
Category
Non-ionic surfactant
> Phenol
>> Ether-group Phenol
Chemical Numbering System
CAS: 3380-34-5
EINECS: 222-182-2
Molecular Formula & Molecular Weight
Molecular Formula: C12H7Cl3O2
Molecular Weight: 289.54
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
84mg/kg[1] |
|
mouse oral LD50 |
4530mg/kg[1] |
|
mouse subcutaneous LD50 |
3800mg/kg[1] |
|
rabbit skin LD50 |
9300mg/kg[1] |
|
rat intraperitoneal LD50 |
89mg/kg[1] |
|
rat intravenous LD50 |
29mg/kg[1] |
|
rat oral LD50 |
3700mg/kg[1] |
|
rat subcutaneous LD50 |
3900mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), QB/T 4947 Cosmetic ingredients -- Triclosan
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimicrobial agent, preservative.
2, Personal care products
Preservative, deodorant in personal care products.
Further information:
(1), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowed preservatives.
Can be applied to:
hand soaps, body soaps/shower gels, deodorants (non-spray), face powders and blemish concealers, nail products. For nail products, not be used more than once every two weeks.
Maximum concentration is 0.3%.
(2), In accordance with EU regulations (EC) No 358/2014, directive 2007/17/EC, be included in Annex V/25.
Can be applied to:
(2a), toothpastes, hand soaps, body soaps/shower gels, deodorants (non-spray), face powders and blemish concealers, nail products.
Nail products for cleaning the fingernails and toenails before the application of artificial nail systems.
Maximum concentration is 0.3%.
(2b), mouthwashes.
Maximum concentration is 0.2%.
Manufacturers
References
[1]: ChemIDplus. 3380-34-5, Triclosan
Update: 20190901(1)