Phytonadione
Synonyms
Vitamin K1;
1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl)-;
Category
Non-ionic surfactant
> Ketone
>> Quinone and its Derivatives
Chemical Numbering System
CAS: 84-80-0 / 11104-38-4
EINECS: 201-564-2 / 234-330-3
Molecular Formula & Molecular Weight
Molecular Formula: C31H46O2
Molecular Weight: 450.70
Structure
Properties
Appearance (1), liquid.
Solubility insoluble in water.
Stability stable. Easily oxidized. Unstable to light.
Risk Liquid form: irritation, irritation to skin, eye.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse oral LD50 |
25000mg/kg[1] |
|
mouse intravenous LD50 |
> 6570mg/kg[1] |
|
mouse subcutaneous LDLo |
1000mg/kg[1] |
|
rat oral LD50 |
> 33487mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
man intramuscular TDLo |
11.429mg/kg/8D[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent emulsifying, dispersing, lubricating abilities. Coagulation function.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Liquid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Liquid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Vitamin K1
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as micronutrient.
2, Medicine
Use as pharmaceutical ingredient (vitamins drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 84-80-0, Phytonadione
Update: 20190804(1);