Thiamine HCl
Synonyms
Thiamine hydrochloride;
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride (1:1), hydrochloride (1:1);
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride, monohydrochloride;
Vitamin B1 hydrochloride;
FEMA No. 3322;
Category
Cationic surfactant
> Quaternary Ammonium Salt
>> Aromatic Heterocyclic Quaternary Ammonium Salt
Chemical Numbering System
CAS: 67-03-8
EINECS: 200-641-8
Molecular Formula & Molecular Weight
Molecular Formula: C12H18Cl2N4OS; C12H17N4OS.Cl.HCl
Molecular Weight: 337.27
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
cat intravenous LD50 |
75mg/kg[1] |
|
frog subcutaneous LD50 |
2600mg/kg[1] |
|
guinea pig intravenous LD50 |
140mg/kg[1] |
|
guinea pig subcutaneous LD50 |
872mg/kg[1] |
|
mouse intraperitoneal LD50 |
200mg/kg[1] |
|
mouse intravenous LD50 |
74mg/kg[1] |
|
mouse oral LD50 |
8224mg/kg[1] |
|
mouse subcutaneous LD50 |
266mg/kg[1] |
|
pigeon intravenous LD50 |
180mg/kg[1] |
|
rabbit intravenous LD50 |
117mg/kg[1] |
|
rat intraperitoneal LD50 |
481mg/kg[1] |
|
rat intravenous LD50 |
118mg/kg[1] |
|
rat oral LD50 |
3710mg/kg[1] |
|
rat subcutaneous LD50 |
560mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
women intramuscular LDLo |
5mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, antibacterial, emulsifying, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB 7295 Feed additive -- Thiamine hydrochloride (Vitamin B1)
(1b), GB 14751 Food additive -- Vitamin B1 (Thiamine hydrochloride)
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antistatic agent.
Use as micronutrient.
2, Personal care products
Conditioning agent, masking agent in personal care products.
3, Food
Use as food additive (perfume).
Use as food nutrition enhancer.
4, Feed
Use as feed additive.
Manufacturers
References
[1]: ChemIDplus. 67-03-8, Thiamine hydrochloride
Update: 20190609(1);