Heparin
Synonyms
Heparinum;
Category
Polymer Surfactant
> Polysaccharide and its Derivatives
>> Anionic-type
>>> Anionic Polysaccharide and its Derivatives
Chemical Numbering System
CAS: 9005-49-6
EINECS: 232-681-7
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
1900mg/kg[1] |
|
mouse intravenous LD50 |
500mg/kg[1] |
|
mouse subcutaneous LD50 |
500mg/kg[1] |
|
rat oral LD50 |
1950mg/kg[1] |
|
rat intraperitoneal LDLo |
420mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
man intravenous TDLo |
3536units/kg/[1] |
|
man subcutaneous TDLo |
1857units/kg/[1] |
|
women subcutaneous TDLo |
0.03mL/kg/5D-I[1] |
|
women subcutaneous TDLo |
48mg/kg/20D-I[1] |
|
women subcutaneous TDLo |
1000units/kg/[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent film-forming, emulsifying, dispersing, lubricating abilities. High anionic charge density. A sulfated mucopolysaccharide.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
Use as lubricant.
2, Personal care products
Conditioning agent in personal care products.
Manufacturers
References
[1]: ChemIDplus. 9005-49-6, Heparin
Update: 20200426(1);