Sodium heparin
Synonyms
Heparin, sodium salt;
Heparin sodium;
Category
Polymer Surfactant
> Polysaccharide and its Derivatives
>> Anionic-type
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Chemical Numbering System
CAS: 9041-08-1
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LD50 |
1000mg/kg[1] |
|
mouse intraperitoneal LD50 |
> 2500mg/kg[1] |
|
mouse intravenous LD50 |
2800mg/kg[1] |
|
mouse oral LD50 |
> 5000mg/kg[1] |
|
mouse subcutaneous LD50 |
> 2500mg/kg[1] |
|
rat intravenous LD50 |
391821IU/kg[1] |
|
rat oral LD50 |
> 779000IU/kg[1] |
|
rat subcutaneous LD50 |
46715IU/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
man subcutaneous TDLo |
7mg/kg/4D[1] |
|
man subcutaneous TDLo |
943mg/kg/47W-[1] |
|
women intravenous TDLo |
700units/kg/1[1] |
|
women subcutaneous TDLo |
1400units/kg/[1] |
|
women subcutaneous TDLo |
3400units/kg/[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent film-forming, emulsifying, dispersing, lubricating abilities. High anionic charge density. A sulfated mucopolysaccharide.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Heparin Sodium
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
Use as lubricant.
2, Personal care products
Conditioning agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (anticoagulant). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 9041-08-1, Heparin sodium
Update: 20200426(1);