Diphenhydramine
Synonyms
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 58-73-1
EINECS: 200-396-7
Molecular Formula & Molecular Weight
Molecular Formula: C17H21NO; C17H21N1O
Molecular Weight: 255.35
Structure
Properties
Appearance (1), liquid.
Solubility slightly soluble in water.
Stability stable.
Risk Liquid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
guinea pig intraperitoneal LD50 |
75mg/kg[1] |
|
guinea pig subcutaneous LD50 |
56mg/kg[1] |
|
mouse intraperitoneal LD50 |
56mg/kg[1] |
|
mouse intravenous LD50 |
29mg/kg[1] |
|
mouse oral LD50 |
160mg/kg[1] |
|
mouse subcutaneous LD50 |
50mg/kg[1] |
|
rat intraperitoneal LD50 |
280mg/kg[1] |
|
rat intravenous LD50 |
42mg/kg[1] |
|
rat oral LD50 |
390mg/kg[1] |
|
rat subcutaneous LD50 |
474mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
0.714mg/kg[1] |
|
women oral TDLo |
30mg/kg[1] |
|
women oral TDLo |
82mg/kg[1] |
|
women oral TDLo |
178mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent emulsifying, dispersing, antistatic, anticorrosive, solubilizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Liquid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Liquid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as emulsifying agent, dispersing agent.
Use as antistatic agent.
Use as pharmaceutical ingredient (antihistamine) (For reference only.).
Manufacturers
References
[1]: ChemIDplus. 58-73-1, Diphenhydramine
Update: 20200822(1);