Hexachlorophene
Synonyms
2,2'-Methylenebis(3,4,6-trichlorophenol);
Category
Non-ionic surfactant
> Phenol
>> Hydrocarbyl Phenol
Chemical Numbering System
CAS: 70-30-4
EINECS: 200-733-8
Molecular Formula & Molecular Weight
Molecular Formula: C13H6Cl6O2
Molecular Weight: 406.90
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LDLo |
5mg/kg[1] |
|
dog oral LDLo |
40mg/kg[1] |
|
guinea pig oral LD50 |
60mg/kg[1] |
|
guinea pig skin LD50 |
1100mg/kg[1] |
|
guinea pig intraperitoneal LDLo |
25mg/kg[1] |
|
mouse inhalation LC50 |
290mg/m3[1] |
|
mouse intraperitoneal LD50 |
20mg/kg[1] |
|
mouse oral LD50 |
67mg/kg[1] |
|
mouse skin LD50 |
270mg/kg[1] |
|
mouse subcutaneous LD50 |
46mg/kg[1] |
|
rabbit intravenous LD50 |
8.5mg/kg[1] |
|
rabbit oral LD50 |
40.69mg/kg[1] |
|
rat inhalation LC50 |
340mg/m3[1] |
|
rat intraperitoneal LD50 |
22mg/kg[1] |
|
rat intravenous LD50 |
7.5mg/kg[1] |
|
rat oral LD50 |
56mg/kg[1] |
|
rat skin LD50 |
1840mg/kg[1] |
|
rat subcutaneous LD50 |
7.65mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
child oral LDLo |
250mg/kg[1] |
|
infant oral TDLo |
257mg/kg/7D-I[1] |
|
women oral TDLo |
600mg/kg[1] |
Overall carcinogenic evaluation: Group 3[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antimicrobial agent, antibacterial agent, preservative, disinfectant.
Use as wood preservative.
Manufacturers
References
[1]: ChemIDplus. 70-30-4, Hexachlorophene
Update: 20190908(1)