Zinc pyrithione
Synonyms
Pyrithione zinc;
Zinc, bis(2-pyridylthio)-, N,N'-dioxide;
(T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc;
ZPT;
Category
Zwitterionic Surfactant
> Amine Oxide
>> Heteroaromatic Amine Oxide
Chemical Numbering System
CAS: 13463-41-7
EINECS: 236-671-3
Molecular Formula & Molecular Weight
Molecular Formula: C10H8N2O2S2Zn
Molecular Weight: 317.72
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog oral LD50 |
600mg/kg[1] |
|
dog intravenous LDLo |
25mg/kg[1] |
|
guinea pig oral LD50 |
> 2000mg/kg[1] |
|
monkey intravenous LDLo |
25mg/kg[1] |
|
mouse intraperitoneal LD50 |
26.8mg/kg[1] |
|
mouse oral LD50 |
160mg/kg[1] |
|
mouse subcutaneous LD50 |
730mg/kg[1] |
|
rabbit skin LD50 |
100mg/kg[1] |
|
rabbit intravenous LDLo |
10mg/kg[1] |
|
rat inhalation LC50 |
140mg/m3/4H[1] |
|
rat oral LD50 |
177mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimicrobial agent, preservative.
2, Personal care products
Preservative, antidandruff agent, antiseborrhoeic agent, conditioning agent in personal care products.
Further information:
(1), (1a), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the restricted components.
Can be applied to leave-on hair products and rinse-off antidandruff hair products.
Maximum concentration is 0.1% in leave-on hair products.
Maximum concentration is 1.5% in rinse-off antidandruff hair products.
(1b), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowed preservatives.
Can be applied to rinse-off products.
Maximum concentration is 0.5% in rinse-off products.
Manufacturers
References
[1]: ChemIDplus. 13463-41-7, Pyrithione zinc
Update: 20140729(1); 20190714(2);