Folic acid
Synonyms
L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-;
Category
Zwitterionic Surfactant
> Amino Acid Type
>> Peptide and its Salts
Chemical Numbering System
CAS: 59-30-3
EINECS: 200-419-0
Molecular Formula & Molecular Weight
Molecular Formula: C19H19N7O6
Molecular Weight: 441.40
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
guinea pig intravenous LD50 |
120mg/kg[1] |
|
mouse intraperitoneal LD50 |
85mg/kg[1] |
|
mouse intravenous LD50 |
282mg/kg[1] |
|
mouse oral LD50 |
10000mg/kg[1] |
|
mouse subcutaneous LDLo |
200mg/kg[1] |
|
rabbit intravenous LD50 |
410mg/kg[1] |
|
rat intravenous LD50 |
500mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent dispersing, emulsifying, antistatic abilities. Micronutrient. Growth substance. A member of the vitamin B family.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB 7302 Feed additive -- Folic acid
(1b), GB 15570 Food additive -- Folic acid
(1c), Chinese Pharmacopoeia (2015 Edition) Folic acid
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Personal care products
Conditioning agent in personal care products.
2, Food
Use as food nutrition enhancer.
3, Feed
Use as feed additive.
4, Medicine
Use as pharmaceutical ingredient (vitamins drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 59-30-3, Folic acid
Update: 20190414(1);