Sodium propylparaben
Synonyms
4-Hydroxybenzoic acid, propyl ester, sodium salt;
Benzoic acid, 4-hydroxy-, propyl ester, sodium salt;
Benzoic acid, p-hydroxy-, propyl ester, sodium salt;
Propylparaben, sodium salt;
Sodium 4-propoxycarbonylphenoxide;
Category
Anionic Surfactant
> Phenolate
Chemical Numbering System
CAS: 35285-69-9
EINECS: 252-488-1
Molecular Formula & Molecular Weight
Molecular Formula: C10H11NaO3; C10H12O3.Na
Molecular Weight: 202.18
Structure
Properties
Appearance (1), white powder.
Solubility soluble in water.
Hygroscopicity hygroscopic.
Stability stable.
Risk Solid form: flammable material; irritation, strong irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LDLo |
85mg/kg[1] |
|
mouse intraperitoneal LD50 |
490mg/kg[1] |
|
mouse intravenous LD50 |
180mg/kg[1] |
|
mouse oral LD50 |
3700mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Sodium Propyl Parahydroxybenzoate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimicrobial agent, preservative.
2, Personal care products
Preservative in personal care products.
Further information:
(1), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowable preservatives.
Maximum dosage:
0.4% (as acid) for single ester;
0.8% (as acid) for mixtures of esters; and the sum of the individual concentrations of propylparaben and its salts and butylparaben and its salts does not exceed 0.14% (as acid).
(2), In accordance with EU regulations (EC) No 1004/2014, be included in Annex V/12 bis.
Dosage:
(2a), 0.14% (as acid) for the sum of the individual components;
(2b), When used in conjunction with the substances listed in Annex V/12, the maximum dosage does not exceed 0.8% (as acid); and the sum of the individual concentrations of propylparaben and its salts and butylparaben and its salts does not exceed 0.14% (as acid).
3, Medicine
Pharmaceutic adjuvant, use as bacteriostatic agent. (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 35285-69-9, Propylparaben sodium
Update: 20130915(1); 20190401(2);