Hydrocortisone sodium succinate
Synonyms
Cortisol, 21-(hydrogen succinate), monosodium salt;
Hydrocortisone 21-(sodium succinate);
Sodium 17-hydroxycorticosterone 21-succinate;
Category
Anionic Surfactant
> Carboxylate
>> Ester Carboxylate
>>> Dicarboxylic Ester Salt
>>> Succinate
Chemical Numbering System
CAS: 125-04-2
EINECS: 204-725-5
Molecular Formula & Molecular Weight
Molecular Formula: C25H33NaO8; C25H34O8.Na
Molecular Weight: 484.51
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable. Under strong acid or strong alkali, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
1050mg/kg[1] |
|
rat intraperitoneal LD50 |
1320mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
man intravenous LDLo |
1.429mg/kg[1] |
|
man intravenous TDLo |
2.857mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent emulsifying, dispersing, solubilizing, lubricating, anti-inflammatory abilities. Glucocorticoid.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
Use as lubricant.
Manufacturers
References
[1]: ChemIDplus. 125-04-2, Hydrocortisone sodium succinate
Update: 20140330(1); 20190215(2);