Sodium salicylate
Synonyms
Benzoic acid, 2-hydroxy-, sodium salt (1:1);
Salicylic acid, monosodium salt;
Category
Anionic Surfactant
> Carboxylate
>> Cyclic Carboxylate
>>> Aryl Carboxylate
>>>> Hydroxybenzoate
Chemical Numbering System
CAS: 54-21-7
EINECS: 200-198-0
Molecular Formula & Molecular Weight
Molecular Formula: C7H5NaO3; C7H6O3.Na
Molecular Weight: 160.10
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LD50 |
562mg/kg[1] |
|
dog intraperitoneal LDLo |
990mg/kg[1] |
|
dog oral LDLo |
450mg/kg[1] |
|
dog subcutaneous LDLo |
200mg/kg[1] |
|
frog subcutaneous LDLo |
250mg/kg[1] |
|
guinea pig intraperitoneal LDLo |
900mg/kg[1] |
|
guinea pig subcutaneous LDLo |
800mg/kg[1] |
|
mouse intramuscular LD50 |
760mg/kg[1] |
|
mouse intraperitoneal LD50 |
500mg/kg[1] |
|
mouse intravenous LD50 |
500mg/kg[1] |
|
mouse oral LD50 |
540mg/kg[1] |
|
mouse subcutaneous LD50 |
550mg/kg[1] |
|
rabbit intravenous LD50 |
415mg/kg[1] |
|
rabbit oral LD50 |
1700mg/kg[1] |
|
rat intraperitoneal LD50 |
542mg/kg[1] |
|
rat oral LD50 |
930mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
human oral LDLo |
700mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative, anti-inflammatory, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as preservative.
2, Personal care products
Preservative, deodorant in personal care products.
* * * * * *
Further information:
(1), In accordance with EU regulations (EC) No 1004/2014, be included in Annex V/3. Maximum concentration is 0.5% (as acid).
Not to be used in products for children under 3 years of age, except for shampoos
To be marked: Not to be used for children under 3 years of age.
(2), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowed preservatives. Maximum concentration is 0.5% (as acid).
Not to be used in products for children under 3 years of age, except for shampoos
To be marked: Not to be used for children under 3 years of age.
Manufacturers
References
[1]: ChemIDplus. 54-21-7, Sodium salicylate
Update: 20140309(1); 20181118(2);