Sodium hyaluronate
Synonyms
Hyaluronic acid, sodium salt;
Hyaluronate sodium;
Category
Polymer Surfactant
> Polysaccharide and its Derivatives
>> Anionic-type
>>> Anionic Polysaccharide and its Derivatives
Chemical Numbering System
CAS: 9067-32-7
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Properties
Appearance (1), white powder.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat oral LD50 |
> 800mg/kg[1] |
|
rat intraperitoneal LD50 |
1770mg/kg[1] |
|
rat subcutaneous LD50 |
> 4000mg/kg[1] |
|
mouse oral LD50 |
> 2400mg/kg[1] |
|
mouse intraperitoneal LD50 |
1500mg/kg[1] |
|
mouse subcutaneous LD50 |
> 4000mg/kg[1] |
|
rabbit oral LD50 |
> 1000mg/kg[1] |
|
rabbit intraperitoneal LD50 |
1820mg/kg[1] |
|
rabbit subcutaneous LD50 |
> 2000mg/kg[1] |
|
dog subcutaneous LD50 |
> 50mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent film-forming, emulsifying, dispersing, lubricating, sustained-release abilities. Good biocompatibility.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), QB/T 4416 Cosmetic ingredients -- Sodium hyaluronate
(1b), QB/T 4576 Sodium hyaluronate
(1c), YY/T 1571 Tissue engineering medical device products -- Sodium hyaluronate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as film-forming agent.
Use as thickening agent.
Use as slow-release agent.
Use as dispersing agent, emulsifying agent.
Use as lubricant.
2, Personal care products
Conditioning agent, humectant in personal care products. Excellent moisturizing, anti-wrinkle effects.
Manufacturers
References
[1]: ChemIDplus. 9067-32-7, Hyaluronate Sodium
Update: 20140911(1); 20200426(2);