Chondroitin 4-sulfate
Synonyms
Chondroitin sulfate A;
Chondroitin, 4-(hydrogen sulfate);
Category
Polymer Surfactant
> Polysaccharide and its Derivatives
>> Anionic-type
>>> Anionic Polysaccharide and its Derivatives
Chemical Numbering System
CAS: 24967-93-9
EINECS: 246-551-2
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Schematic formula:
Properties
Appearance (1), white to slightly yellow powder.
Solubility soluble in water.
Stability stable. Under strong acid condition, easily degraded.
Risk Solid form: irritation, irritation to skin, eye.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intravenous LD50 |
1580mg/kg[1] |
|
mouse oral LD |
> 15000mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent emulsifying, dispersing, film-forming, thickening abilities. Acidic mucopolysaccharide.
Synthesis
US patent 6,342,367 (Method for the preparation of chondroitin sulfate compounds) presents a preparation process.
US patent 9,149,572 (Chondroitin sulfate having decreased molecular weight and use thereof) describes a low molecular weight chondroitin sulfate.
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Actives, %, ≥ |
85.0 |
|
Loss on drying, %, ≤ |
10.0 |
Test Methods
(1), Actives
(2), Loss on drying
105°C, 4h.
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
(c), Used in medicine, must comply with pharmacopoeia execution.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
Use as thickening agent.
2, Personal care products
Reference to chondroitin sulfates.
3, Medicine
Use as pharmaceutical ingredient. (The contents of this section are for reference only and should be subject to pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 24967-93-9, Chondroitin sulfate A
Update: 20131022(1); 20170225(2);