L-Tryptophan
Synonyms
L-Alanine, 3-(1H-indol-3-yl)-;
L-alpha-Amino-3-indolepropionic acid;
Tryptophan;
Trp;
Category
Zwitterionic Surfactant
> Amino Acid Type
>> Amino acid and its Salts
Chemical Numbering System
CAS: 73-22-3
EINECS: 200-795-6
Molecular Formula & Molecular Weight
Molecular Formula: C11H12N2O2
Molecular Weight: 204.23
Structure
Properties
Appearance (1), white solid.
Solubility soluble in water.
Physical - chemical properties
|
Water solubility, g/L |
11.4 (25°C)[1] |
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
4800mg/kg[2] |
|
mouse oral LDLo |
15000mg/kg[2] |
|
rat intraperitoneal LD50 |
1634mg/kg[2] |
|
rat oral LD50 |
> 16000mg/kg[2] |
Reproductive effect[2].
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
300mg/kg[2] |
|
man oral TDLo |
857mg/kg/30D-[2] |
|
women oral TDLo |
2700mg/kg/13W[2] |
|
women oral TDLo |
3276mg/kg/9W-[2] |
|
women oral TDLo |
4800mg/kg/34W[2] |
|
women oral TDLo |
5400mg/kg/134[2] |
|
women oral TDLo |
9000mg/kg/22W-I[2] |
|
women oral TDLo |
10960mg/kg/20[2] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, dispersing, emulsifying, anticorrosive abilities. Essential amino acid. Amino acid that make up proteins.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
Ninhydrin method
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB/T 25735 Feed additive -- L-Tryptophan
(1b), Chinese Pharmacopoeia (2015 Edition) Tryptophan
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent, emulsion stabilizer.
2, Personal care products
Conditioning agent, antistatic agent, masking agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (amino acids drug).
Pharmaceutic adjuvant, use as solubilizer, freeze-drying protectant.
(This section is for reference only, should be implemented according to local Pharmacopoeia.)
4, Food
Use as food nutrition enhancer.
5, Feed
Use as feed additive.
Manufacturers
References
[1]: HSDB. 73-22-3, L-Tryptophan
[2]: ChemIDplus. 73-22-3, Tryptophan
Update: 20190414(1);