L-Histidine
Synonyms
Histidine;
FEMA No. 3694;
His;
Category
Zwitterionic Surfactant
> Amino Acid Type
>> Amino acid and its Salts
Chemical Numbering System
CAS: 71-00-1
EINECS: 200-745-3
Molecular Formula & Molecular Weight
Molecular Formula: C6H9N3O2
Molecular Weight: 155.15
Structure
Properties
Appearance (1), white solid.
Solubility soluble in water.
Physical - chemical properties
|
Water solubility, g/L |
45.6 (25°C)[1] |
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
> 10000mg/kg[2] |
|
mouse intravenous LD50 |
> 2000mg/kg[2] |
|
mouse oral LD50 |
> 15000mg/kg[2] |
|
mouse subcutaneous LD50 |
> 10000mg/kg[2] |
|
rat intraperitoneal LD50 |
> 8000mg/kg[2] |
|
rat intravenous LD50 |
> 2000mg/kg[2] |
|
rat oral LD50 |
> 15000mg/kg[2] |
|
rat subcutaneous LD50 |
> 10000mg/kg[2] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, dispersing, emulsifying abilities. Essential amino acid. Amino acid that make up proteins.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
Ninhydrin method
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Histidine
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent, emulsion stabilizer.
2, Personal care products
Conditioning agent, antistatic agent, humectant in personal care products.
3, Food
Use as food additive (perfume).
4, Medicine
Use as pharmaceutical ingredient (amino acids drug).
Pharmaceutic adjuvant, use as solubilizer, freeze-drying protectant.
(This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: HSDB. 71-00-1, L-Histidine
[2]: ChemIDplus. 71-00-1, Histidine
Update: 20190414(1);