Protamine sulfate
Synonyms
Protamine, sulfate;
Protamines, sulfates;
Sulfuric acid, protamine salt;
Category
Polymer Surfactant
> Protein and its Derivatives
>> Protein and its Salts
Chemical Numbering System
CAS: 9009-65-8
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
guinea pig intraperitoneal LD50 |
120mg/kg[1] |
|
guinea pig intravenous LD50 |
120mg/kg[1] |
|
guinea pig subcutaneous LD50 |
200mg/kg[1] |
|
mouse intraperitoneal LD50 |
94mg/kg[1] |
|
mouse intravenous LD50 |
38mg/kg[1] |
|
mouse subcutaneous LD50 |
200mg/kg[1] |
|
rabbit subcutaneous LD50 |
200mg/kg[1] |
|
rat intraperitoneal LD50 |
120mg/kg[1] |
|
rat intravenous LD50 |
75mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
man intravenous LDLo |
2174ug/kg/25M[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent film-forming, dispersing, antistatic, emulsifying, adsorbing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Protamine Sulfate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as film-forming agent.
Use as dispersing agent, emulsifying agent.
2, Personal care products
Conditioning agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (antiheparin drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 9009-65-8, Protamine sulfate
Update: 20140818(1); 20201030(2);