Tolnaftate
Synonyms
Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl ester;
Category
Non-ionic surfactant
> Ester
>> Carbamic Ester
Chemical Numbering System
CAS: 2398-96-1
EINECS: 219-266-6
Molecular Formula & Molecular Weight
Molecular Formula: C19H17NOS; C19H17N1O1S
Molecular Weight: 307.41
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog oral LD50 |
> 14000mg/kg[1] |
|
guinea pig oral LD50 |
> 4000mg/kg[1] |
|
mouse intraperitoneal LD50 |
120mg/kg[1] |
|
mouse intravenous LD50 |
4800mg/kg[1] |
|
mouse oral LD50 |
10000mg/kg[1] |
|
mouse subcutaneous LD50 |
> 6000mg/kg[1] |
|
rabbit intravenous LD |
> 50mg/kg[1] |
|
rat oral LD50 |
> 6000mg/kg[1] |
|
rat subcutaneous LD50 |
> 4000mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimicrobial agent.
2, Personal care products
Antimicrobial agent in personal care products.
Manufacturers
References
[1]: ChemIDplus. 2398-96-1, Tolnaftate
Update: 20141014(1); 20200607(2);