Methyl salicylate
Synonyms
Benzoic acid, 2-hydroxy-, methyl ester;
Salicylic acid, methyl ester;
FEMA No. 2745;
Category
Non-ionic surfactant
> Phenol
>> Ester-group Phenol
Chemical Numbering System
CAS: 119-36-8
EINECS: 204-317-7
Molecular Formula & Molecular Weight
Molecular Formula: C8H8O3
Molecular Weight: 152.15
Structure
Properties
Appearance (1), liquid.
Odor holly-like odor.
Solubility slightly soluble in water.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Liquid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog oral LD50 |
2100mg/kg[1] |
|
dog subcutaneous LDLo |
2250mg/kg[1] |
|
guinea pig oral LD50 |
700mg/kg[1] |
|
guinea pig subcutaneous LDLo |
1500mg/kg[1] |
|
mouse oral LD50 |
1110mg/kg[1] |
|
rabbit oral LD50 |
1300mg/kg[1] |
|
rabbit subcutaneous LDLo |
4250mg/kg[1] |
|
rat oral LD50 |
887mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
child oral LDLo |
228mg/kg[1] |
|
child oral LDLo |
700mg/kg[1] |
|
human oral LDLo |
506mg/kg[1] |
|
infant oral LDLo |
1480mg/kg[1] |
|
man oral LDLo |
101mg/kg[1] |
|
man oral LDLo |
1329mg/kg[1] |
|
women oral LDLo |
355mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent masking, dispersing, anti-inflammatory, anti-oxidizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Liquid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Liquid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB 28355 Food safety national standard -- Food additive -- Methyl salicylate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as perfume.
Use as UV absorbing agent.
Use as solvent.
Use as intermediates in organic synthesis.
2, Personal care products
Soothing agent, perfume, denaturant in personal care products.
3, Food
Use as food additive (perfume).
Manufacturers
References
[1]: ChemIDplus. 119-36-8, Methyl salicylate
Update: 20140929(1); 20190908(2)