Ethinylestradiol
Synonyms
19-Nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol;
19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-;
Ethinyl estradiol;
Category
Non-ionic surfactant
> Phenol
> Steroids
Chemical Numbering System
CAS: 57-63-6
EINECS: 200-342-2
Molecular Formula & Molecular Weight
Molecular Formula: C20H24O2
Molecular Weight: 296.40
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
250mg/kg[1] |
|
mouse oral LD50 |
950mg/kg[1] |
|
mouse subcutaneous LD50 |
> 3000mg/kg[1] |
|
rat intraperitoneal LD50 |
471mg/kg[1] |
|
rat oral LD50 |
960mg/kg[1] |
|
rat subcutaneous LD50 |
> 2000mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
women oral TDLo |
21mg/kg/21D-I[1] |
Reasonably anticipated to be a carcinogen[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent dispersing, emulsifying, lubricating abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
Use as lubricant.
Use as intermediate in organic synthesis.
Manufacturers
References
[1]: ChemIDplus. 57-63-6, Ethinylestradiol
Update: 20130920(1); 20190901(2)