D-Mannitol
Synonyms
Mannitol;
Category
Non-ionic surfactant
> Alcohol
>> Fatty Alcohol
Chemical Numbering System
CAS: 69-65-8
EINECS: 200-711-8
Molecular Formula & Molecular Weight
Molecular Formula: C6H14O6
Molecular Weight: 182.17
Structure
Properties
Appearance (1), solid; (2), liquid.
Solubility soluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
14000mg/kg[1] |
|
mouse intravenous LD50 |
7470mg/kg[1] |
|
mouse oral LD50 |
22000mg/kg[1] |
|
rat intravenous LD50 |
9690mg/kg[1] |
|
rat oral LD50 |
13500mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
man intravenous TDLo |
17143mg/kg/2D[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent dispersing, emulsifying, hydrotropic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB 1886.177 Food safety national standard -- Food additive -- D-Mannitol
(1b), GB/T 32096 Mannitol for industry
(1c), Chinese Pharmacopoeia (2015 Edition) Mannitol
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as non-nutritive sweetener.
Use as dispersing agent, emulsifying agent.
Use as intermediate in organic synthesis.
Use as anticaking agent.
2, Personal care products
Conditioning agent, humectant, masking agent in personal care products.
3, Food
Use as food additive (sweetener, emulsifier, bulking agent, stabilizer, thickener), food processing aid (anticaking agent, processing technology of candy).
4, Medicine
Use as pharmaceutical ingredient (dehydrating agent). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 69-65-8, Mannitol
Update: 20130920(1); 20190915(2)