Diethylene glycol
Synonyms
2,2'-Oxybisethanol;
2,2'-Oxydiethanol;
DEG;
Category
Non-ionic surfactant
> Ether
Chemical Numbering System
CAS: 111-46-6
EINECS: 203-872-2
Molecular Formula & Molecular Weight
Molecular Formula: C4H10O3
Molecular Weight: 106.12
Structure
Properties
Appearance (1), colorless liquid.
Solubility soluble in water.
Stability stable.
Risk Liquid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
cat oral LD50 |
3300mg/kg[1] |
|
dog oral LD50 |
9000mg/kg[1] |
|
guinea pig oral LD50 |
7800mg/kg[1] |
|
mouse inhalation LCLo |
130mg/m3/2H[1] |
|
mouse intraperitoneal LD50 |
9719mg/kg[1] |
|
mouse oral LD50 |
23700mg/kg[1] |
|
mouse subcutaneous LDLo |
5000mg/kg[1] |
|
rabbit oral LD50 |
4400mg/kg[1] |
|
rabbit skin LD50 |
11890mg/kg[1] |
|
rabbit intramuscular LDLo |
4472mg/kg[1] |
|
rabbit intravenous LDLo |
2236mg/kg[1] |
|
rat intraperitoneal LD50 |
7700mg/kg[1] |
|
rat intravenous LD50 |
6565mg/kg[1] |
|
rat oral LD50 |
12565mg/kg[1] |
|
rat subcutaneous LD50 |
18800mg/kg[1] |
|
rat intramuscular LDLo |
7826mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
child oral TDLo |
2400mg/kg[1] |
|
human oral LDLo |
1000mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent cleansing, solubilizing, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Liquid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Liquid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as cleansing agent.
Use as solvent.
2, Personal care products
(1), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the prohibited components.
(2), In accordance with EU regulations (EC) No 344/2013, be included in Annex II/1370 and III/186.
As traces in ingredients, maximum concentration is 0.1%.
3, Organic synthesis
Use as intermediate. For example, synthesis of polyurethane, polyester, plasticizers, surfactants.
4, Vehicle
Use as antifreezing agent.
Manufacturers
References
[1]: ChemIDplus. 111-46-6, Diethylene glycol
Update: 20130920(1); 20190825(2)