PVP-Iodine
Synonyms
PVP-I;
2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine;
2-Pyrrolidinone, 1-vinyl-, polymers, compd. with iodine;
Povidone Iodine;
Category
Polymer Surfactant
> Polyenes
>> Non-ionic Polyenes
Chemical Numbering System
CAS: 25655-41-8
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Properties
Appearance (1), brown powder; or liquid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intravenous LD50 |
480mg/kg[1] |
|
mouse oral LD50 |
8100mg/kg[1] |
|
mouse subcutaneous LD50 |
4100mg/kg[1] |
|
rat intravenous LD50 |
640mg/kg[1] |
|
rat oral LD50 |
>8000mg/kg[1] |
|
rat subcutaneous LD50 |
3450mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 1 Human toxicity values
|
human skin TDLo |
3400mg/kg/24H[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Liquid / Solid |
|
|
Actives, %, ≥ |
|
|
I2, %, ≥ |
10.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
(2), I2
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Liquid / Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Povidone Iodine
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antimicrobial agent, disinfectant.
2, Medicine
Use as pharmaceutical ingredient (disinfect and antiseptic drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 25655-41-8, Povidone-iodine
Update: 20140903(1); 20201009(2);