Chlorhexidine digluconate
Synonyms
Chlorhexidine gluconate;
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate;
Category
Cationic Surfactant
> Guanidine Salt
Chemical Numbering System
CAS: 18472-51-0
EINECS: 242-354-0
Molecular Formula & Molecular Weight
Molecular Formula: C34H54Cl2N10O14; C22H30Cl2N10.2C6H12O7
Molecular Weight: 897.76
Structure
Properties
Appearance (1), white solid; (2), liquid.
Solubility soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intravenous LD50 |
12.9mg/kg[1] |
|
mouse oral LD50 |
1260mg/kg[1] |
|
mouse subcutaneous LD50 |
1140mg/kg[1] |
|
rat intravenous LD50 |
24.2mg/kg[1] |
|
rat oral LD50 |
2000mg/kg[1] |
|
rat subcutaneous LD50 |
3320mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative, antistatic abilities. Do not contact with metal (such as iron, aluminum).
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Chlorhexidine Gluconate Solution
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimicrobial agent, antibacterial agent, preservative.
2, Personal care products
Antimicrobial agent, preservative, oral care agent in personal care products.
Further information:
(1), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowed preservatives.
Maximum concentration is 0.3% (as Chlorhexidine).
(2), In accordance with EU regulations (EC) No 1223/2009, directive 2007/17/EC, be included in Annex V/42.
Maximum concentration is 0.3% (as Chlorhexidine).
3, Medicine
Use as antiseptic and antiseptic. (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 18472-51-0, Chlorhexidine digluconate
Update: 20130924(1); 20200329(2);